Large increases in adipose triacylglycerol flux in Cushingoid CRH-Tg mice are explained by futile cycling
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چکیده
منابع مشابه
Large increases in adipose triacylglycerol flux in Cushingoid CRH-Tg mice are explained by futile cycling.
Glucocorticoids are extremely effective anti-inflammatory therapies, but their clinical use is limited due to severe side effects, including osteoporosis, muscle wasting, fat redistribution, and skin thinning. Here we use heavy water labeling and mass spectrometry to measure fluxes through metabolic pathways impacted by glucocorticoids. We combine these methods with measurements of body composi...
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The universally observed exponential increase in soil-surface CO2 e ux (‘soil respiration’; FS) with increasing temperature has led to speculation that global warming will accelerate soilorganic-carbon (SOC) decomposition1, reduce SOC storage, and drive a positive feedback to future warming2. However, interpreting temperature–FS relationships, and so modelling terrestrial carbon balance in a wa...
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The manipulation of cofactor pools such as ATP or NAD(P)H has for long been recognized as key targets for metabolic engineering of microorganisms to improve yields and productivities of biotechnological processes. Several works in the past have shown that enforcing ATP futile cycling may enhance the synthesis of certain products under aerobic conditions. However, case studies demonstrating that...
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BACKGROUND Obesity is associated with low-grade chronic inflammation attributed to dysregulated production, release of cytokines and adipokines and to dysregulated glucose-insulin homeostasis and dyslipidemia. Nutritional interventions such as dieting are often accompanied by repeated bouts of weight loss and regain, a phenomenon known as weight cycling (WC). METHODS In this work we studied t...
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UNLABELLED Metabolism plays an important role in the persister phenotype, as evidenced by the number of strategies that perturb metabolism to sabotage this troublesome subpopulation. However, the absence of techniques to isolate high-purity populations of native persisters has precluded direct measurement of persister metabolism. To address this technical challenge, we studied Escherichia coli ...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Endocrinology and Metabolism
سال: 2013
ISSN: 0193-1849,1522-1555
DOI: 10.1152/ajpendo.00154.2012